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Online Tool

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This tool displays the synaptic connectivity of C. elegans in your browser window. After neuron classes are chosen, click the "Submit" button to display their wiring data and diagram.
  • When only a single neuron class (the number of chosen neuron classes N=1) is chosen, the number of synapses between its neuron class and others is displayed.
  • When two or more neuron classes (N≥2) are chosen, the number of synapses between them is displayed.
  • When fifteen or less neuron classes (N≤15) are chosen, wiring diagram is also displayed together with wiring table. JavaScript needs to be enabled ("ON") on your browser to display the diagram.
  • Symbols in the brackets represent
      "se": sensory neuron,   "in": interneuron,   "mo": motor neuron,   "un": unknown function
    whose data source is mainly WormAtlas.

   

A: ADA(in) ADE(se) ADF(se) ADL(se) AFD(se) AIA(in)
AIB(in) AIM(in) AIN(in) AIY(in) AIZ(in) ALA(in)
ALM(se) ALN(un) AQR(se) AS(mo) ASE(se) ASG(se)
ASH(se) ASI(se) ASJ(se) ASK(se) AUA(in) AVA(in)
AVB(in) AVD(in) AVE(in) AVF(in) AVG(in) AVH(in)
AVJ(in) AVK(in) AVL(in/mo) AVM(se) AWA(se) AWB(se)
AWC(se)
B,C: BAG(se) BDU(in) CAN(un)[*] CEP(se)
D: DA(mo) DB(mo) DD(mo) DVA(in) DVB(mo/in) DVC(in)
F,H: FLP(se) HSN(mo)
I,L: I1(in) I2(in) I3(in) I4(in) I5(in) I6(in)
IL1(se/mo) IL2(se) LUA(in)
M,N: M1(mo) M2(mo) M3(mo/se) M4(mo) M5(mo) MC(mo/se)
MI(mo/in) NSM(mo)
O: OLL(se) OLQ(se)
P: PDA(mo) PDB(mo) PDE(se) PHA(se) PHB(se) PHC(se)
PLM(se) PLN(in) PQR(se) PVC(in) PVD(se) PVM(se)
PVN(in/mo) PVP(in) PVQ(in) PVR(in) PVT(in) PVW(in)
R: RIA(in) RIB(in) RIC(in) RID(in) RIF(in) RIG(in)
RIH(in) RIM(mo) RIP(in) RIR(in) RIS(in) RIV(in)
RMD(mo/in) RME(mo) RMF(mo/in) RMG(in) RMH(mo/in)
S: SAA(in) SAB(in) SDQ(in) SIA(in) SIB(in) SMB(mo/in)
SMD(mo/in)
U: URA(mo) URB(in/se) URX(in) URY(se)
V: VA(mo) VB(mo) VC(mo) VD(mo)
Others(-)[**]

[*] No synaptic data of CAN is found.
[**] Cells and tissue other than the neurons: "CEPsh[DL,DR,VL,VR]"(cephalic sheath cells), "GLR[DL,DR,L,R,VL,VR]"(thin cylindrical sheet cells between pharynx and ring neuropil), "MUSCLE"(neuromuscular junction), "VUL"(vulval muscle, vm2), "HDC"(hypodermis), "bm"(pharyngeal basement membrane), "g"(pharyngeal gland cells), "m[1-8]"(pharyngeal muscle cells) and "mc"(pharyngeal marginal cells). These cells and tissue are not displayed in wiring diagram.

   


NOTES

  • Sources of the synaptic connectivity are the following data files in the database[3].
    (a) synapse_WF.txt: somatic nervous system presented in the figures in the paper[1]
    (b) synapse_WT.txt: somatic nervous system presented in the tables in the paper[1]
    (c) White_Text.txt: synaptic connectivity of PDA and PDB neuron classes presented in the text (pp.215-216) in the paper[1]
    (d) synapse_AF.txt: pharyngeal nervous system presented in the figures in paper[2]

  • Several ambiguous or questionable descriptions are found in the original papers[1,2]. Different interpretation and handling of these descriptions might cause a difference in the computed number of synapses. For this reason, these descriptions are not improved in the database[3] (the above four data files). Instead of improvement, the comment index is attached to the corresponding data. It is the work of users to improve these descriptions according to their own policy. The details of improvement in this tool is presented in this page.
      analysis of anatomical data in the original papers[1,2] and improvement in this tool

  • In addition, there is a problem that the connectivity data in the file (a) and that in (b) are not complementary each other [White, personal communication]. Therefore data mergence of them would lead to double-counting of the synapses. In this tool, the synaptic connectivity computed with the file (a) and that with (b) are displayed separately. If the number of synapses shown in this tool is different from that in other synaptic connectivity database, the difference comes from the above mentioned reasons.

  • If the connection data is consistent, the number of synapses which "A" neuron sends to "B" neuron (#Send(A --> B)) is equal to the number of synapses which "B" neuron receive from "A" neuron (#Receive(B <-- A)), that is, #Send(A --> B) = #Receive(B <-- A). The anatomical data in the paper[1] almost satisfies this relation, however, there are a few inconsistent data. In such cases, this tool displays only the greater number of them, that is,
        the number of synapses from "A" to "B" neuron = MAX( #Send(A --> B), #Receive(B <-- A) )

REFERENCES
  1. J. G. White, E. Southgate, J. N. Thomson and S. Brenner, "The Structure of the Nervous System of the Nematode Caenorhabditis elegans", Phil. Trans. R. Soc. London, B 314 (1986) 1-340.
  2. D. G. Albertson and J. N. Thomson, "The Pharynx of Caenorhabditis elegans", Phil. Trans. R. Soc. London, B 275 (1976) 299-325.
  3. K. Oshio, Y. Iwasaki, S. Morita, Y. Osana, S. Gomi, E. Akiyama, K. Omata, K. Oka and K. Kawamura, "Database of Synaptic Connectivity of C. elegans for Computation", Technical Report of CCeP, Keio Future, No.3, (2003) Keio University.

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